天津市新药安全评价研究中心LOGO
释药技术与药代动力学国家重点实验室
天津药物研究院
强大的研究团队
联系我们
地 址:滨海高新区滨海科技园惠仁道308号 电 话: 022-84845242 联系人:伊老师 邮 箱:drugtransporter@126.com
研究室动态研究室动态研究室动态
高水平高质量的研究成果
发布时间:2012-12-04 文章来源:释药技术与药代动力学国家重点实验室-天津药物研究院

1. Herbdrug Interactions Involving Drug Metabolizing Enzymes and Transporters. Current Drug Metabolism, 2011, 12, 835-849

2. Drug Metabolism and Pharmacokinetics of Nanodrugs from Chinese Medicines and Natural Products. Current Drug Metabolism, 2012, 13, 659-666

3. Quantitation of ursolic acid in human plasma by ultra performance liquid chromatography tandem mass spectrometry and its pharmacokinetic study. Journal of Chromatography B, 2011, 879, 219-224

4. Synthesis and Preliminary Antibacterial Evaluation of 2-Butyl Succinate-based Hydroxamate Derivatives Containing Isoxazole Rings. Arch Pharm Res, 2010, 33, 831-842

5. Chemical study and medical application of saponins as anti-cancer agents. Fitoterapia, 2010, 81, 703-714

6. Quantitation of catalpol in rat plasma by liquid chromatography/electrospray ionization tandem mass spectrometry and its pharmacokinetic study. Journal of Chromatography B, 2009, 877, 3589-3594

7. Qualitative and quantitative determination of major saponins in Paris and Trillium by HPLC-ELSD and HPLC–MS/MS. Journal of Chromatography B, 2010, 878, 2943-294

8. Rapid and sensitive LC-MS method for pharmacokinetic study of vinorelbine in rats. Biomed Chromatogr, 2009, 23, 909-911.

9. An integrated metabonomic method for profiling of metabolic changes in carbon tetrachloride induced rat urine. Toxicology, 2009, 256, 191-200.

10.Antidiarrhoeal and intestinal modulatory activities of Wei-Chang-An-Wan extract. Journal of Ethnopharmacology, 2009, 125, 450-455.

11. Identification of Chemical Constituents in Extracts and Rat Plasma from Fructus Aurantii by UPLC-PDA-Q-TOF/MS. Phytochem Anal, 2011, 22, 112-118.

12.Antitumor and antimetastatic activities of Rhizoma Paridis saponins. Steroids, 2009, 74, 1051-1056.

13. Pharmacokinetics of new molecular entity (NME) and new biologic license application (BLA) approvals in 2009. Asian Journal of Pharmacodynamics and Pharmacokinetics, 2010, 10, 93-121.

14. Phase 0 clinical trials: An efficient way to development of new drugs. Asian Journal of Pharmacodynamics and Pharmacokinetics, 2010, 10, 261-270.

15. Simultaneous Determination of Tegafur and Gimeracil in Human Plasma by Liquid Chromatography/Tandem Mass Spectrometry. Analytical Sciences, 2009.

16. Translational research in drug discovery, research and development. Asian Journal of Pharmacodynamics and Pharmacokinetics, 2010, 10, 247-260.

17. Female Rhesus Monkeys A 30-Day Preclinical Safety Evaluation Study of Recombinant Human Follicle-Stimulating Hormone in Female Rhesus Monkeys. International Journal of Toxicology, 30, 153-161.

18. An engineered superantigen SEC2 exhibits promising antitumor activity and low toxicity. Cancer Immunol Immunother, 2011, 60, 705-713.

19. Chemical fingerprint analysis of Phellodendri Amurensis Cortex by ultra performance LC/Q-TOF-MS methods combined with chemometrics. J Sep Sci, 2010, 33, 3347-3353.

20. LC/MS/MS and radioisotope method combined for recognizing the af?nity between catalpol and OCT2 transporter. Frontiers of Chemical Science and Engineering, 2012.

21. Effects of adlay seed oil on blood lipids and antioxidant capacity in hyperlipidemic rats. J Sci Food Agric, 2011, 91, 1843-1848.

22. Evaluation of the in Vivo Anti-inflammatory Effects of Extracts from Pyrus bretschneideri Rehd. J Agric Food Chem, 2010, 58, 8983-8987.

23. Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain Its Low Plasma Levels in Rats. DMD, 2010, 38, 1779-1784.

24. Formosanin C-inhibited pulmonary metastasis through repression of matrix metalloproteinases on mouse lung adenocarcinoma. Cancer Biology & Therapy, 2011, 11, 592-598.

25. Identification of chemical constituents in Rhizoma Paridis Saponins and their oral administration in rat plasma by UPLC/Q-TOF/MS. Biomed. Chromatogr, 2011, 25, 712-719.

26. Inhibition of matrix metalloproteinases related to metastasis by diosgenyl and pennogenyl saponins. Journal of Ethnopharmacology, 2011, 137, 1221-1227.

27. M3 muscarinic receptor-and Ca2+ influx-mediated muscle contractions induced by croton oil in isolated rabbit jejunum. Journal of Ethnopharmacology, 2010, 129, 377-380.

28. Pharmacokinetics of panaxatrol disuccinate sodium, a novel anti-cancer drug from Panax notoginseng, in healthy volunteers and patients with advanced solid tumors. Acta Pharmacologica Sinica, 2010, 31, 1515-1522.

29. Pharmacokinetics of vertilmicin, a novel aminoglycoside antibiotic, in rats and dogs. Eur J Drug Metab Pharmacokinet, 2010, 35, 47-53.

30. Pharmacokinetics, tissue distribution, excretion, and antiviral activity of pegylated recombinant human consensus interferon-α variant in monkeys, rats and guinea pigs. Regulatory Peptides, 2011.

31. Research and Application of Targeting Nano-Drugs. Nano Biomed Eng, 2011, 3, 73-83.

32. The Effects of Salvianolic Acid B from Radix Salvia Miltiorrhizae on the Oral Pharmacokinetics of Metoprolol and Metoprolol Acid in Rats. Phytother Res, 2010, 24, 846-851.

33. 应用药物转运体的药代动力学评价. 药物评价研究, 2010.

34. Inhibitory effect of several organic carboxyl acids originated from medicinal plants on human transporters hOAT1, hOAT3, hOATP1B1 and hOATP2B1. Chinese Journal of Natural Medicines, accept, 2012.

35. 塞来昔布胶囊犬口服给药的体内过程及一致性评价. 中国临床药理学与治疗学, 接收, 2012.

36. 乳香提取物中AKBA 在Caco-2和MDCK-MDR1两种细胞模型中的吸收研究. 中草药, 接收, 2012.

37. 应用MDCK-MDR1细胞模型研究乳香提取物中AKBA 血脑屏障透过机制. 中国新药杂志, 接收, 2012.

狼人综合干练伊人,97碰碰碰超视频视频,日本一级特黄视频播放,538prom精品视频在线播放